Railway companies of South Carolina

List of railway companies in the American state of South Carolina.

Class I railways

 * Amtrak (AMTK), passenger on freight lines
 * Chesapeake Southern Railway (CHS), freight
 * Pennsylvania Seaboard Railroad (PS), freight
 * Piedmont & Northern Railway (PN), freight and passenger

Shortline and terminal railways

 * Aiken Railway (AIKR), freight
 * Carolina Coastal Railway (CLNA), freight
 * Carolina Piedmont Railroad (CPDR), freight
 * East Cooper & Berkeley Railroad (ECBR), freight
 * Hampton & Branchville Railroad (HB), freight
 * Lancaster & Chester Railroad (LC), freight
 * Pee Dee River Railway (PDRR), freight
 * Pickens Railway (PICK), freight
 * Port Terminal Railroad of South Carolina (PTR), freight
 * Port Utilities Commission of Charleston (PUCC), freight
 * South Carolina Central Railroad (SCCR), freight

Defunct railways
Years shown here refer to the period in which a given company operated in South Carolina; they may have existed elsewhere before or after these years.